Dataset Information
MODEL2427021978_url.xml
Ontology highlight
ABSTRACT: Increased glycolytic flux as an outcome of whole-genome duplication in yeast. This is the original model reproducing figure 3A of the article submitted by the authors. There exists a curated version with BIOMD0000000176 that reproduces figures 2A,3A and 3B from the publication. BIOMD0000000176 encompasses MODEL2426780967, MODEL2427021978, MODEL2427095802. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2011 The BioModels.net Team. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..
GC Conant and KH Wolfe, Mol Syst Biol 3:129,2007
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: administrator
PROVIDER: MODEL2427021978 | biostudies-other |
SECONDARY ACCESSION(S): 17667951
REPOSITORIES: biostudies-other
Publications
Increased glycolytic flux as an outcome of whole-genome duplication in yeast.
Molecular systems biology 20070731
After whole-genome duplication (WGD), deletions return most loci to single copy. However, duplicate loci may survive through selection for increased dosage. Here, we show how the WGD increased copy number of some glycolytic genes could have conferred an almost immediate selective advantage to an ancestor of Saccharomyces cerevisiae, providing a rationale for the success of the WGD. We propose that the loss of other redundant genes throughout the genome resulted in incremental dosage increases fo ...[more]