Dataset Information
Lo2016 – IBD Response to Anti-TNFα treatment
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: bastien chassagnol
PROVIDER: MODEL2505090001 | biostudies-other |
SECONDARY ACCESSION(S): 27824890
REPOSITORIES: biostudies-other
Publications
Inflammatory Bowel Disease: How Effective Is TNF-α Suppression?
PloS one 20161108 11
Crohn's Disease (CD) results from inappropriate response toward commensal flora. Earlier studies described CD as a Th1 mediated disease. Current models view both phenotypes as a continuum of various permutations between Th1, Th2 and Th17 pathways compounded by a range of Treg disfunctions. In the present paper, we develop a mathematical model, by a system of differential equations, which describe the dynamic relations among these T cells and their cytokines. The model identities four groups of C ...[more]
