Dataset Information
Wu2006_K+Channel
Ontology highlight
ABSTRACT: The model is described in the paper by Wu and Chang (2006). Diethyl pyrocarbonate, a histidine-modifying agent, directly stimulates activity of ATP-sensitive potassium channels in pituitary GH3 cells. Biochem Pharmacol. 71(5): 615-23. The unit of time is ms, and the simulation time is 80 s, that is 8e4 ms. Therfore, you probably need to increase the maximum steps for your simulator. The figure 7 has been reproduced by MathSBML. Application of DEPC as indicated at horizontal bar was mimicked by an increase of maximal conductance of Katp-channels from 500 to 530 ps at t=30 s. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
ORGANISM(S): Rattus
SUBMITTER: Lucian Smith
PROVIDER: MODEL2981976537 | biostudies-other |
SECONDARY ACCESSION(S): 16375866
REPOSITORIES: biostudies-other
Publications
A calcium-based phantom bursting model for pancreatic islets.
Bulletin of mathematical biology 20040901 5
Insulin-secreting beta-cells, located within the pancreatic islets of Langerhans, are excitable cells that produce regular bursts of action potentials when stimulated by glucose. This system has been the focus of mathematical investigation for two decades, spawning an array of mathematical models. Recently, a new class of models has been introduced called 'phantom bursters' [Bertram et al. (2000) Biophys. J. 79, 2880-2892], which accounts for the wide range of burst frequencies exhibited by isle ...[more]
