Yates2007_TcellHomeostasisProliferation

ABSTRACT:

This a model from the article:
Understanding the slow depletion of memory CD4+ T cells in HIV infection.
Yates A, Stark J, Klein N, Antia R, Callard R. PLoS Med. 2007;4(5):e177. 17518516 ,
Abstract:
BACKGROUND: The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4(+) T cells. Why this decline is slow is not understood. One potential explanation is that the low average rate of homeostatic proliferation or immune activation dictates the pace of a "runaway" decline of memory CD4(+) T cells, in which activation drives infection, higher viral loads, more recruitment of cells into an activated state, and further infection events. We explore this hypothesis using mathematical models. METHODS AND FINDINGS: Using simple mathematical models of the dynamics of T cell homeostasis and proliferation, we find that this mechanism fails to explain the time scale of CD4(+) memory T cell loss. Instead it predicts the rapid attainment of a stable set point, so other mechanisms must be invoked to explain the slow decline in CD4(+) cells. CONCLUSIONS: A runaway cycle in which elevated CD4(+) T cell activation and proliferation drive HIV production and vice versa cannot explain the pace of depletion during chronic HIV infection. We summarize some alternative mechanisms by which the CD4(+) memory T cell homeostatic set point might slowly diminish. While none are mutually exclusive, the phenomenon of viral rebound, in which interruption of antiretroviral therapy causes a rapid return to pretreatment viral load and T cell counts, supports the model of virus adaptation as a major force driving depletion.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Yates A, Stark J, Klein N, Antia R, Callard R. (2007) - version03
The original CellML model was created by:
Lloyd, Catherine, May
[e-mail]
The University of Auckland
The Bioengineering Institute

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ORGANISM(S): Human immunodeficiency virus 1

SUBMITTER: Vijayalakshmi Chelliah 

PROVIDER: MODEL4028801312 | biostudies-other |

SECONDARY ACCESSION(S): 17518516

REPOSITORIES: biostudies-other