Banaji2005_Brain_Cell_Metabolism

ABSTRACT:

This is a part of the model described in:
A physiological model of cerebral blood flow control
Murad Banaji, Ilias Tachtsidis, David Delpy, Stephen Baigent, Mathematical biosciences 2005 194:125-173; PMID: 15854674 , doi: 10.1016/j.mbs.2004.10.005
Abstract:
The construction of a computational model of the human brain circulation is described. We combine an existing model of the biophysics of the circulatory system, a basic model of brain metabolic biochemistry, and a model of the functioning of vascular smooth muscle (VSM) into a single model. This represents a first attempt to understand how the numerous different feedback pathways by which cerebral blood flow is controlled interact with each other. The present work comprises the following: Descriptions of the physiology underlying the model; general comments on the processes by which this physiology is translated into mathematics; comments on parameter setting; and some simulation results. The simulations presented are preliminary, but show qualitative agreement between model behaviour and experimental results.

The model represents the intracellular component of the model, and is translated from the implementation available with the braincirc package.

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Kieran Smallbone 

PROVIDER: MODEL4992089662 | biostudies-other |

SECONDARY ACCESSION(S): 15854674

REPOSITORIES: biostudies-other