Dataset Information
Chassagnole2001_Threonine Synthesis
Ontology highlight
ABSTRACT: . . . SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS . . . . . . Biomodels Curation: The model reproduces Fig 2f of the paper. The Vmax values for different reactions are obtained by multiplying the specific activites given in Table 3 of the paper with the protein concentration and an assay correction factor that was provided by the authors. The protein concentration is 202 mg/litre. The specific activities that need to be taken into consideration are those given for "variable threonine" in Table 3. The following are the assay correction factors provided by the authors: vak1=1.49; vak3=1.12; vasd=1.14; vhsd=1.42; vts=1.15; vhk=1.13. The model was successfully tested on MathSBML and Jarnac
Run this model online at http://jjj.biochem.sun.ac.za
To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online , Bioinformatics, 20:2143-2144
ORGANISM(S): Escherichia coli (strain K12)
SUBMITTER: Lucian Smith
PROVIDER: MODEL6624131052 | biostudies-other |
SECONDARY ACCESSION(S): 11368770
REPOSITORIES: biostudies-other
Publications
Control of the threonine-synthesis pathway in Escherichia coli: a theoretical and experimental approach.
The Biochemical journal 20010601 Pt 2
A computer simulation of the threonine-synthesis pathway in Escherichia coli Tir-8 has been developed based on our previous measurements of the kinetics of the pathway enzymes under near-physiological conditions. The model successfully simulates the main features of the time courses of threonine synthesis previously observed in a cell-free extract without alteration of the experimentally determined parameters, although improved quantitative fits can be obtained with small parameter adjustments. ...[more]
