Zhang2000_Peripheral_Sinoatrial_Node

ABSTRACT:

This the model describing the action potentials of the peripheral rabbit sinoatrial node from the article:
Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node.
Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. Am J Physiol Heart Circ Physiol. 2000 Jul;279(1):H397-421. Pubmed ID: 10899081 , full text at AJP - Heart and Circulatory Physiology.
Abstract:
Mathematical models of the action potential in the periphery and center of the rabbit sinoatrial (SA) node have been developed on the basis of published experimental data. Simulated action potentials are consistent with those recorded experimentally: the model-generated peripheral action potential has a more negative takeoff potential, faster upstroke, more positive peak value, prominent phase 1 repolarization, greater amplitude, shorter duration, and more negative maximum diastolic potential than the model-generated central action potential. In addition, the model peripheral cell shows faster pacemaking. The models behave qualitatively the same as tissue from the periphery and center of the SA node in response to block of tetrodotoxin-sensitive Na(+) current, L- and T-type Ca(2+) currents, 4-aminopyridine-sensitive transient outward current, rapid and slow delayed rectifying K(+) currents, and hyperpolarization-activated current. A one-dimensional model of a string of SA node tissue, incorporating regional heterogeneity, coupled to a string of atrial tissue has been constructed to simulate the behavior of the intact SA node. In the one-dimensional model, the spontaneous action potential initiated in the center propagates to the periphery at approximately 0.06 m/s and then into the atrial muscle at 0.62 m/s.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Zhang, Holden, Kodama, Honjo, Lei, Varghese, Boyett, 2000, version03
The original CellML model was created and curated by:
Garny, Alan
alan.garny(at)dpag.ox.ac.uk
University of Oxford

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

ORGANISM(S): Oryctolagus cuniculus

SUBMITTER: Lukas Endler 

PROVIDER: MODEL6962035527 | biostudies-other |

SECONDARY ACCESSION(S): 10899081

REPOSITORIES: biostudies-other