Hyaluronic Acid is a Biomarker for Allograft Dysfunction and Predicts 1-year Outcome after Liver Transplantation

ABSTRACT: Introduction: Allograft dysfunction after liver transplantation has a profound impact on risk of death and retransplantation within the first year. We tested whether elevated hyaluronic acid (HA) (a glycosaminoglycan cleared by hepatic sinusoidal endothelium) and bacterial translocation (reflected by elevated soluble CD14 (sCD14)) levels may predict excess risk of graft loss. Methods: This is a retrospective single center prognostic cohort study. Patients with either a plasma sample pretransplant, an early post-transplant sample nearest day 30 (range 10-89 days, 80% within day 15 to 60) or both were included. Plasma HA and sCD14 were measured using enzyme-linked immunosorbent assays. The primary endpoint was 1-year graft loss (all-cause mortality and re-plantation). Secondary endpoint was

SUBMITTER: Andreas Arendtsen Rostved 

PROVIDER: S-BSST102 | biostudies-other |

REPOSITORIES: biostudies-other