The gut microbiome contributes to somatic morphine withdrawal behavior and implicates a TLR2 mediated mechanism

ABSTRACT: The ongoing opioid epidemic has left millions of people suffering from opioid use disorder due to the over-prescription of highly addictive substances. Chronic opioid exposure leads to dependence, where the absence of the drug results in negative symptoms of withdrawal, often driving patients to continue drug use; however, few therapeutic strategies are currently available to combat the cycle of addiction and the severity of morphine withdrawal. This study investigates the microbiome as a potential therapeutic target for morphine withdrawal, as gut dysbiosis caused by morphine use has been proven to contribute to other aspects of opioid use disorders, such as tolerance. Results show that although the microbiome during morphine withdrawal trends toward recovery from morphine-induced dysbios

ORGANISM(S): mouse gut metagenome

SUBMITTER:  

PROVIDER: S-BSST1068 | biostudies-other |

REPOSITORIES: biostudies-other