Cytogenetic characterization of triple-hit B-cell lymphoma cell line SC-1 reveales novel chromosomal aberration t(14;17)(q32;q21) activating HOXB5 and miR10a.

ABSTRACT: BCL2, BCL6 and MYC represent major oncogenes in B-cell lymphoma. They are activated via chromosomal translocations juxtaposing IGH to BCL2 and MYC, and by fusion of diverse partner genes with BCL6. So called double-hit lymphomas carry BCL2 and MYC rearrangements while triple-hit lymphomas contain additionally BCL6-fusions. These translocations are of diagnostic importance and associated with poor prognosis. Here, we cytogenetically and genomically characterized triple-hit B-cell lymphoma cell line SC-1 which carries t(14;18)(q32;q21) targeting IGH and BCL2, t(8;14)(q24;q32) juxtaposing IGH and MYC, and t(3;3)(q25;q27) fusing MBNL1 and BCL6. In addition, we detected a novel chromosomal rearrangement, t(14;17)(q32;q21), which was mapped by FISH and analyzed by gene expression profiling. This

ORGANISM(S): Homo sapiens (human)

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PROVIDER: S-BSST1073 | biostudies-other |

REPOSITORIES: biostudies-other