PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins

ABSTRACT: Plasma membrane integrity (PMI) is essential for cellular homeostasis; thus, pore-forming toxins (PFTs) that disrupt host PMI significantly contribute to the virulence of various pathogens. However, how host cells protect PMI in response to PFT perforation in vivo remains obscure. Previously, we demonstrated that the HLH-30/TFEB-dependent intrinsic cellular defense (INCED) is elicited by PFT to maintain PMI in Caenorhabditis elegans intestinal epithelium. HLH-30/TFEB is a master transcription factor of autophagy, yet the molecular mechanism for the full activation of HLH-30/TFEB by PFT remains elusive. Here, we reveal that protein arginine methyltransferase-7 (PRMT-7) is indispensable to the nuclear transactivation of HLH-30. We demonstrated that PRMT-7 participates in the methylation of H

ORGANISM(S): Caenorhabditis elegans

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PROVIDER: S-BSST1125 | biostudies-other |

REPOSITORIES: biostudies-other