Respiratory disease following viral lung infection alters the murine gut microbiota

ABSTRACT: Alterations in the composition of the gut microbiota have profound effects on human health. Consequently there is great interest in identifying, characterising and understanding factors which initiate these changes. Despite their high prevalence, only recently have studies begun to look at how viral lung infections impact on the gut microbiota. There is also considerable interest in whether the gut microbiota could be manipulated during vaccination to improve efficacy. In this highly-controlled study, we aimed to establish the effect of viral lung infection on gut microbiota composition and the gut environment using mouse models of common respiratory pathogens Respiratory Syncytial Virus (RSV) and influenza virus. This was then compared to the effect of live attenuated influenza virus (LAI

SUBMITTER: Helen Groves 

PROVIDER: S-BSST116 | biostudies-other |

REPOSITORIES: biostudies-other