Fecal DNA methylation signatures marking gut dysbiosis and inflammation in children affected by autism spectrum disorders

ABSTRACT: Gut brain axis involves several bidirectional pathways communications including microbiome, bacterial metabolites, neurotransmitters as well as immune system and is perturbed both in brain and in gastrointestinal disorders. Consistently, microbiota-gut-brain axis has been found altered in autism spectrum disorder (ASD). We reasoned that such alterations occurring in ASD, may impact both on methylation signatures of human fecal DNA (HFD) and possibly on the types of human cells shed in the stools from intestinal tract giving origin to HFD. To test this hypothesis, we have performed whole genome methylation analysis of HFD from an age-restricted cohort of young children with ASD and healthy controls. For the same cohort we have previously investigated the fecal microbiota composition and fec

ORGANISM(S): Homo sapiens (human)

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PROVIDER: S-BSST1160 | biostudies-other |

REPOSITORIES: biostudies-other