Establishment of the myeloid TBX-code reveales aberrant expression of T-box gene TBX1 in chronic myeloid leukemia

ABSTRACT: (1) Background: T-box (TBX) genes encode transcription factors involved in the control of developmental processes and in carcinogenesis if deregulated. Recently, we have established the lymphoid TBX-code, showing TBX gene activities in normal lymphopoiesis and enabling identification of deregulated gene members in lymphoid malignancies. Here, we extended this analysis for myelopoiesis, generating the myeloid TBX-code to study myeloid tumor types. (2) Methods: We bioinformatically analyzed published TBX gene expression data for normal and malignant cells. Model cell lines were examined by RQ-PCR, Western blot, genomic profiling, siRNA-mediated knockdown and RNA-seq analysis, in addition to live-cell imaging. (3) Results: The established myeloid TBX-code contains 10 T-box genes including ste

ORGANISM(S): Homo sapiens (human)

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PROVIDER: S-BSST1176 | biostudies-other |

REPOSITORIES: biostudies-other