IRX-related homeobox gene MKX is a novel oncogene in acute myeloid leukemia and multiple myeloma

ABSTRACT: Homeobox genes encode transcription factors which organize differentiation processes in cells and tissues including hematopoiesis. Recently, we have reported restricted physiological expression of TALE-class homeobox gene IRX1 in early myelopoiesis at the megakaryocyte-erythroid-progenitor stage and in early B-cell development at the pro-B-cell stage, while IRX3 and IRX5 are aberrantly activated in the corresponding malignancies acute myeloid leukemia (AML) and progenitor B-cell acute lymphoid leukemia. Here, we examined the role of IRX-related homeobox gene MKX (IRXL1 or mohawk) in normal and malignant hematopoiesis. Screening of 100 leukemia/lymphoma cell lines revealed MKX expression in AML and multiple myeloma (MM) derived cell lines. While MKX was silent in normal myelopoiesis and B-c

ORGANISM(S): Homo sapiens (human)

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PROVIDER: S-BSST1315 | biostudies-other |

REPOSITORIES: biostudies-other