Differential effects of areca nut, tobacco, and lime on oral squamous cell carcinoma progression Authors

ABSTRACT: Consumption of tobacco and its associated products has been linked with a high incidence of oral cancer in the Indian subcontinent. The present study aims to assess the differential effect of areca nut, tobacco, and slaked lime on the pathogenesis and progression of oral cancer. Extracts of areca nut (ANE), tobacco leaf (TLE), and lime water (LWE) were prepared and characterized. Oral keratinocyte cells (BICR10) were treated with the prepared extracts alone and in combinations. Cell apoptosis, necrosis, nuclear aberrations, and transcript expression profiles were assessed to study the cancer pathogenesis. An increase in apoptosis and necrosis was observed in the cells treated with ANE and ANE+LWE, while a decrease in apoptosis was observed in cells treated with TLE. We also found a variati

ORGANISM(S): Homo sapiens (human)

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PROVIDER: S-BSST1495 | biostudies-other |

REPOSITORIES: biostudies-other