Causal Relationship between the Gut Microbiota, Immune Cells, and Coronary Heart Disease: A Mediated Mendelian Randomization Analysis

ABSTRACT: Background: Recent studies have shown that gut microbiota (GM), immune cells, and coronary heart disease (CHD) are closely related, but the causal nature is largely unknown. This study aimed to investigate this causal relationship and to reveal the effect of GM, immune cells on the risk of developing CHD using mediated Mendelian randomization (MR) analysis. Methods: Firstly, we looked for the data related to GM, immune cells, and CHD through published genome-wide association studies (GWAS), filtered the SNPs (single nucleotide polymorphisms) related to GM and immune cells, and then performed the first MR analysis to get the disease-associated intestinal bacteria and disease-associated immune cells. Then, three MR analyses were performed: disease-associated GM to disease-associated immune

ORGANISM(S): Homo sapiens (human)

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PROVIDER: S-BSST1516 | biostudies-other |

SECONDARY ACCESSION(S): 10.3389/fmicb.2024.1449935

REPOSITORIES: biostudies-other