A critical role of cyclophilin D in the survival of senescent cells

ABSTRACT: We show that senescent cells are highly vulnerable to elevated mitochondrial Ca2+ and transient CypD/mPTP opening is a critical survival adaptation mechanism. Thus, we propose CypD as a novel senolytic target.

ORGANISM(S): Homo sapiens (human) Mus musculus (mouse)

SUBMITTER:  

PROVIDER: S-BSST1617 | biostudies-other |

REPOSITORIES: biostudies-other