Effect Of Diet And Genotype On The Lipidome Of Plasma, Liver And Aorta Of Mice With Altered Lipoprotein Metabolism

ABSTRACT: The impact of PCSK9 and LDLR on plasma cholesterol levels is well known, but their effect on the entire lipidome is lacking. This issue is relevant, since several lipid species, circulating at very low concentrations, can impair lipid metabolism and promote atherosclerosis development. This study characterized and compared plasma, liver and aorta lipidomes of i) wild-type, ii) hypercholesterolemic Ldlr-KO and iii) hypocholesterolemic Pcsk9-KO mice fed a standard chow or a Western-type diet up to 30 and 16 weeks of age, respectively. 42 lipid species including cholesterol, cholesteryl esters, several sphingolipids, phospholipids and lysophospholipids, accumulated uniquely in the atherosclerotic aorta of Western-type diet-fed Ldlr-KO mice. In addition, multiple organ/tissue comparisons allow

ORGANISM(S): Mus musculus (mouse)

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PROVIDER: S-BSST1634 | biostudies-other |

REPOSITORIES: biostudies-other