SiO2 nanoparticles as disruptors of endogenous resolution mechanisms of inflammatory responses that exacerbate pneumonia

ABSTRACT: Abstract Occupational exposure to engineered nanomaterials (ENMs) is increasing in the workplace and can impact human health. Amorphous silicon dioxide nanoparticles (SiO2 NPs) are widely produced respirable ENMs used in commercial products. We have investigated their impact on lung inflammation resolution and bacterial defense. Mice exposed to SiO2 NPs, followed by bacteria, exhibited increased lung inflammation, bacterial proliferation, and lung damage compared to mice not exposed to NPs. SiO2 NPs increased human macrophage production of pro-inflammatory mediators and disrupted phagocytosis of bacteria and efferocytosis of apoptotic neutrophils - pivotal responses for host defense and inflammation resolution. A pro-resolving mediator, resolvin D5 (RvD5), restored macrophage phagocytosis

ORGANISM(S): Mus musculus (mouse)

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PROVIDER: S-BSST1666 | biostudies-other |

REPOSITORIES: biostudies-other