Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Toxicological data on macrophages exposed to true to life polyethylene terephthalate nanoparticles

ABSTRACT: These data are tabulated data obtained when carrying out targeted toxicological assays of different types. The model system is represented by macrophages, which have been exposed to polyethylene terephthalate nanoparticles

ORGANISM(S): Mus musculus (mouse)

SUBMITTER:

PROVIDER: S-BSST1693 | biostudies-other |

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

Dose dependent toxicological response of lung cells exposed to silica nanoparticles

2015-03-01 | GSE63806 | GEO

Dose dependent toxicological response of lung cells exposed to silica nanoparticles

Project description:We have employed whole genome microarray expression to distinguish the effect of Fumed Silica Nanoparticles on human alveolar epithelial A549 lung cells. Cells were exposed in vitro, and datasets of differentially expressed genes were identified for NPs versus control samples. NPs induced gene expression in A549 cells was measured at 24 hours and 72 hours after exposure. Minimum three independent experiments were performed for each experiment.

2015-03-01 | E-GEOD-63806 | biostudies-arrayexpress

Toxicological data on macrophages exposed to micro and nano plastics

Project description: Not available

| S-BSST1470 | biostudies-other

Toxicological data on copper oxide-based nanoparticles

Project description: Not available

| S-BSST2833 | biostudies-other

Toxicological Evaluations in Macrophages and Mice Acutely and Chronically Exposed to Halloysite Clay Nanotubes Functionalized with Polystyrene.

Project description: Not available

| S-EPMC8582073 | biostudies-literature

Toxicological data on macrophages exposed to iron oxide pigments used in tattooing

Project description: Not available

| S-BSST2099 | biostudies-other

Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes.

Project description: Not available

| S-EPMC5946698 | biostudies-literature

About the effects of true to life polyethylene terephthalate nanoparticles on macrophages

Project description:Plastics are emerging pollutants of great concern. Macroplastics degrade into microplastics and nanoplastics, which can accumulate in living organisms with still poorly known consequences. Nanoplastics being particulate pollutants, they are handled in animal organisms by scavenger cells such as macrophages, which are important players in the immune system. Polyethylene terephthalate is one of these plastics of concern, as it is widely used in food packaging where it releases nanoparticles. We have thus undertaken a study on the effects of true-to-life polyethylene terephthalate nanoparticles prepared from water bottles on macrophages. To this purpose, we used a combination of proteomics and targeted validation experiments. Proteomics showed important adaptive changes in the proteome in response to exposure to polyethylene terephthalate nanoparticles. These changes affected for example mitochondrial, cytoskeletal and lysosomal proteins, but also proteins implicated in immune functions. Validation experiments showed that many of these changes were homeostatic, with no induced oxidative stress and no gross perturbation of the mitochondrial function. However, polyethylene terephthalate nanoparticles induced endoplasmic reticulum stress and disturbed the immune functions of macrophages. We indeed observed a slight pro-inflammatory response (1.5-fold increase in TNF secretion). We also observed a decrease in the response to bacterial stimulation (1.6 decrease in IL-6 secretion). We also observed a 20 percent decrease in the expression of important proteins involved in immune responses such as TLR2, TLR7 or collectin 12, and a two-fold decrease in the production of lysozyme. This suggests that macrophages having ingested polyethylene terephthalate nanoparticles are less efficient in their immune functions.

2025-04-09 | PXD062730 | Pride

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper.

Project description: Not available

| S-EPMC3774564 | biostudies-literature

Toxicological Evaluation of SiO₂ Nanoparticles by Zebrafish Embryo Toxicity Test.

Project description: Not available

| S-EPMC6413002 | biostudies-literature