Multi-omics analysis in primary T cells elucidates mechanisms behind disease associated genetic loci

ABSTRACT: Genome-wide association studies (GWAS) have revealed the genetic basis behind many diseases, but interpreting them is challenging as most loci affect regulatory regions. Chromatin conformation is crucial in gene regulation, often used to link potential target genes to regulatory regions. However, past studies used small sample sizes and immortalized cell lines instead of primary cells. Here, we present the largest dataset of chromatin conformation with matching gene expression and chromatin accessibility from primary CD4+ and CD8+ T cells, isolated from psoriatic arthritis patients and healthy controls. We generated 108 Hi-C libraries (49 billion reads), 128 RNA-seq libraries, and 126 ATAC-seq libraries. These data enhance our understanding of how GWAS variants affect gene regulation, sho

ORGANISM(S): Homo sapiens (human)

SUBMITTER:  

PROVIDER: S-BSST1819 | biostudies-other |

SECONDARY ACCESSION(S): http://bartzabel.ls.manchester.ac.uk/orozcolab/SNP2Mechanism/PsA_output_hic_plots/main.html

REPOSITORIES: biostudies-other