4D-DIA proteomics and transcriptomics of thyroid cancer subtypes

ABSTRACT: Formalin-fixed paraffin-embedded (FFPE) tissue samples were obtained from 120 patients, including anaplastic thyroid carcinoma (ATC, n=35), poorly differentiated thyroid carcinoma (PDTC, n=18), papillary thyroid carcinoma (PTC, n=37), and adjacent normal tissues (N, n=30). All samples were confirmed histologically using hematoxylin and eosin (HE) staining and classified according to the 2022 WHO Classification of Thyroid Tumors. For 4D-DIA proteomics analysis, 34 ATC samples, 18 PDTC samples, 36 PTC samples, and 30 N samples passed quality control for further examination. Shanghai OE Biotech Company provided services in micro-proteomics. Proteins were extracted from FFPE sections after dewaxing and rehydration, using the iST Sample Preparation Kit 8x. ue to RNA degradation and occasionally

ORGANISM(S): Homo sapiens (human)

SUBMITTER:  

PROVIDER: S-BSST1925 | biostudies-other |

REPOSITORIES: biostudies-other