SRAS1.1 E3 Ligase Mediates DSK2A Degradation to Regulate Autophagy and Drought Tolerance in Arabidopsis

ABSTRACT: Drought stress significantly impacts plant growth and productivity, requiring complex adaptive responses to ensure survival. In eukaryotes, autophagy and the ubiquitin-proteasome system (UPS) are critical pathways for maintaining cellular homeostasis under stress. While their interaction is well-studied in animals, it remains poorly understood in plants, particularly under drought conditions. Here, we identify the E3 ubiquitin ligase SRAS1.1 as a key regulator of selective autophagy and drought tolerance in Arabidopsis, mediating its function through the ubiquitination and degradation of the autophagy receptor DSK2A. Loss of SRAS1.1 enhances drought tolerance by reducing water loss, increasing survival rates, and accelerating flowering. SRAS1.1 directly interacts with and ubiquitinates the

ORGANISM(S): Arabidopsis thaliana (thale cress)

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PROVIDER: S-BSST1961 | biostudies-other |

REPOSITORIES: biostudies-other