Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GNAS/PKA pathway promotes aberrant osteochondral differentiation of Gli1+ tendon sheath progenitors

ABSTRACT: Source data for Gli1+ tendon sheath progenitors in heterotopic ossification

ORGANISM(S): Mus musculus (mouse)

SUBMITTER:

PROVIDER: S-BSST2091 | biostudies-other |

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

GNAS/PKA pathway promotes aberrant osteochondral differentiation of Gli1+ tendon sheath progenitors

Project description:We have employed a single cell sequencing approach using 10x Genomics scRNAseq to study the identity and fate determination of Gli1+ tendon sheath progenitors in heterotopic ossification(HO) formation following tenotomy. Gli1 is a signature gene for several tissue-specific Mesenchymal stem cells (MSCs). Aberrant osteochondral differentiation of MSCs in soft tissues leads to incorrect tissue regeneration into HO. This study demonstrated a subpopulation of Gli1+ tendon sheath cells that function as tendon stem/progenitors and can initially differentiate into normal or osteochondral tendon-lineage progenitors, with the latter subsequently giving rise to chondrocytes and osteocytes in development of tendon HO.

2025-07-28 | GSE298748 | GEO

GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1<sup>+</sup> tendon sheath progenitors.

Project description: Not available

| S-EPMC12528478 | biostudies-literature

GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1+ tendon sheath progenitors

Project description: Not available

| S-SCDT-10_1038-S44318-025-00553-7 | biostudies-other