Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effects of pentoxifylline in patients with chronic Chagas cardiomyopathy: a randomized, double-blind, controlled pilot trial.

ABSTRACT: This dataset originates from a randomized, double-blind, placebo-controlled trial evaluating the effects of pentoxifylline on inflammatory, functional, and perfusion parameters in patients with chronic Chagas cardiomyopathy. It includes anonymized clinical, laboratory, echocardiographic, myocardial perfusion scintigraphy, and quality-of-life data collected at baseline and after 6 months of treatment.

ORGANISM(S): Homo sapiens (human)

SUBMITTER: Denise Mayumi Tanaka

PROVIDER: S-BSST2186 | biostudies-other |

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

Effects of pentoxifylline in patients with chronic Chagas cardiomyopathy: a randomized, double-blind, controlled pilot trial.

Project description: Not available

| S-BSST2185 | biostudies-other

Effects of pentoxifylline in patients with chronic Chagas cardiomyopathy: A randomized, double-blind, controlled pilot trial.

Project description: Not available

| S-EPMC12558611 | biostudies-literature

Lactiplantibacillus plantarum P9 for chronic diarrhea in young adults: a large double-blind, randomized, placebo-controlled trial

Project description:Fecal untargeted metabolome analysis of patients with chronic diarrhea.

2024-07-10 | MSV000095296 | MassIVE

Dexamethasone for Dyspnea in Cancer Patients: A Pilot Double-Blind, Randomized, Controlled Trial.

Project description: Not available

| S-EPMC4958556 | biostudies-literature

Statin Induced Regression of Cardiomyopathy Trial: A Randomized, Placebo-controlled Double-blind Trial.

Project description: Not available

| S-EPMC5363087 | biostudies-literature

Effects of Synergism of Mindfulness Practice Associated With Transcranial Direct-Current Stimulation in Chronic Migraine: Pilot, Randomized, Controlled, Double-Blind Clinical Trial.

Project description: Not available

| S-EPMC8692277 | biostudies-literature

High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled trial.

Project description: Not available

| S-EPMC3417221 | biostudies-literature

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: a Randomized Double-blind Placebo-controlled Trial

Project description:The gut microbiota has been implicated in obesity and cardiometabolic diseases, although evidence in humans is scarce. We investigated how gut microbiota manipulation by antibiotics (7-day administration of amoxicillin, vancomycin, or placebo) affects host metabolism in 57 obese, prediabetic men. Vancomycin, but not amoxicillin, decreased bacterial diversity and reduced Firmicutes involved in short-chain fatty acid and bile acid metabolism, concomitant with altered plasma and/or fecal metabolite concentrations. Adipose tissue gene expression of oxidative pathways was upregulated by antibiotics, whereas immune-related pathways were downregulated by vancomycin. Antibiotics did not affect tissue-specific insulin sensitivity, energy/substrate metabolism, postprandial hormones and metabolites, systemic inflammation, gut permeability, and adipocyte size. Importantly, energy harvest, adipocyte size, and whole-body insulin sensitivity were not altered at 8-week follow-up, despite a still considerably altered microbial composition, indicating that interference with adult microbiota by 7-day antibiotic treatment has no clinically relevant impact on metabolic health in obese humans. This randomized, placebo-controlled, double-blind study had a 3-armed parallel design. Overweight/obese participants were randomized to oral intake of amoxicillin, vancomycin or placebo for 7 consecutive days. After an overnight fast, subcutaneous adipose tissue biopsies were taken that were subjected to gene expression profiling by array.

2016-07-15 | E-GEOD-76003 | biostudies-arrayexpress

The effects of qishen granules for patients with chronic heart failure: A multicenter randomized double-blind placebo-controlled trial.

Project description: Not available

| S-EPMC9822771 | biostudies-literature

Feasibility and Preliminary Effects of the BESMILE-HF Program on Chronic Heart Failure Patients: A Pilot Randomized Controlled Trial.

Project description: Not available

| S-EPMC8353081 | biostudies-literature