Molecular characterization of the effect of glucagon-like peptide-1 receptor agonist semaglutide in the nephrotoxic serum nephritis mouse model.

ABSTRACT: Mice were treated with semaglutide or the angiotensin-converting enzyme inhibitor enalapril for 14 days. Various kidney function parameters were measured, and gene expression in key kidney compartments was explored using spatial transcriptomics and single-nucleus RNA sequencing in kidney samples collected at the end of the study.

ORGANISM(S): Mus musculus (mouse)

SUBMITTER: Jaime Moreno 

PROVIDER: S-BSST2222 | biostudies-other |

REPOSITORIES: biostudies-other