Combinatory Multifactor Treatment Effects on Primary Nanofiber Oligodendrocyte Cultures

ABSTRACT: Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system. Neurological deficits are attributed to inflammatory demyelination, which compromises axonal function and survival. These are mitigated in experimental models by rapid and often complete remyelination of affected axons, but in MS this endogenous repair mechanism frequently fails, leaving axons increasingly vulnerable to the detrimental effects of inflammatory and metabolic stress. Understanding the molecular basis of remyelination and remyelination failure is essential to develop improved therapies for this devastating disease. However, recent studies suggest that this is not due to a single dominant mechanism, but rather represents the biological outcome of multiple

ORGANISM(S): Mouse

SUBMITTER: Lukas Enz 

PROVIDER: S-BSST300 | biostudies-other |

REPOSITORIES: biostudies-other