Common genetic associations between age-related diseases

ABSTRACT: Data description: Supplementary tables and summary statistics for the paper. Abstract: Age is a common risk factor in many diseases, but the molecular basis for this relationship is elusive. In this study we identified 4 disease clusters from 116 diseases in UK Biobank data, defined by their age-of-onset profiles and found that diseases with the same age profile are genetically more similar, suggesting a common etiology. This similarity was not explained by disease categories, co-occurrences or disease cause-effect relationships. Two of the four disease clusters had an increased risk of occurrence from age 20 and 40 years respectively. They both showed an association with known aging-related genes yet had different functional and evolutionary profiles. We tested mutation accumulation and

ORGANISM(S): Homo sapiens

SUBMITTER: Handan Melike Donertas 

PROVIDER: S-BSST407 | biostudies-other |

REPOSITORIES: biostudies-other