Genome-wide landscape of gene-metabolome associations in Escherichia coli

ABSTRACT: Analyzed metabolome of > 3800 single gene deletion mutants of Escherichia coli. Abstract of publication: Metabolism is one of the best‐understood cellular processes whose network topology of enzymatic reactions is determined by an organism's genome. The influence of genes on metabolite levels, however, remains largely unknown, particularly for the many genes encoding non‐enzymatic proteins. Serendipitously, genomewide association studies explore the relationship between genetic variants and metabolite levels, but a comprehensive interaction network has remained elusive even for the simplest single‐celled organisms. Here, we systematically mapped the association between > 3,800 single‐gene deletions in the bacterium Escherichia coli and relative concentrations of > 7,000 intracellular met

ORGANISM(S): Escherichia coli

SUBMITTER: Tobias Fuhrer 

PROVIDER: S-BSST5 | biostudies-other |

REPOSITORIES: biostudies-other