CKAP2L promotes non-small cell lung cancer progression through regulation of transcription elongation

ABSTRACT: ABSTRACT Chromosomal instability (CIN) is a driver of clonal diversification and intra-tumor heterogeneity, providing genetic diversity that contributes to tumor progression. It is estimated that ?80% of solid cancers, including non-small cell lung cancer (NSCLC), exhibit features of CIN, which affect tumor growth and response to therapy. However, the molecular mechanism connecting CIN to carcinogenesis is still poorly understood. Through an RNAi screen performed on genes involved in CIN and overexpressed in human lung adenocarcinoma samples we identified the Cytoskeleton-associated protein 2-like (CKAP2L) as a potential oncogene that promotes lung cancer cell proliferation and growth in vitro and in vivo. Mechanistically, CKAP2L directly interacts with RNA Pol II and regulates transcripti

ORGANISM(S): Homo sapiens (human)

SUBMITTER: Michela Garofalo 

PROVIDER: S-BSST569 | biostudies-other |

REPOSITORIES: biostudies-other