Biological network approach for the identification of regulatory long non-coding RNAs associated with metabolic efficiency in cattle

ABSTRACT: Genomic regions associated with divergent livestock feed efficiency have been found predominantly outside protein coding sequences. Long non-coding RNAs (lncRNA) can modulate chromatin accessibility, gene expression and are supposed to act as important metabolic regulators in mammals. By integrating phenotypic, transcriptomic and metabolomic data with QTL data in prioritizing co-expression network analyses, we aimed to identify and functionally characterize lncRNAs with a potential key regulatory role in metabolic efficiency in cattle. Crossbred animals (n = 48) of a Charolais x Holstein F2-population were allocated to groups of high or low metabolic efficiency based on residual feed intake (RFI) in bulls, energy corrected milk in cows and intramuscular fat content in both genders. Tissue

ORGANISM(S): Bos Taurus (cow)

SUBMITTER: Daniel Zerbino 

PROVIDER: S-BSST599 | biostudies-other |

SECONDARY ACCESSION(S): PRJEB34570

REPOSITORIES: biostudies-other