Distinct N and C cross-feeding networks in a synthetic mouse gut consortium

ABSTRACT: The complex interactions between gut microbiome and host or pathogen colonization resistance cannot solely be understood from community composition. Missing are causal relationships such as metabolic interactions among species to better understand what shapes the microbiome. Here, we focused on metabolic niches generated and occupied by the Oligo-Mouse-Microbiota, a synthetic community composed of 12 members that is increasingly used as a model for the mouse gut microbiome. Combining mono-cultures and spent medium experiments with untargeted metabolomics uncovered broad metabolic diversity in the consortium, constituting a dense cross-feeding network with more than 100 pairwise interactions. Quantitative analysis of the cross-feeding network revealed distinct C and N food webs that highlig

ORGANISM(S): Mus musculus (mouse)

SUBMITTER:  

PROVIDER: S-BSST686 | biostudies-other |

REPOSITORIES: biostudies-other