Integrative Multi-Omic characterization of LYN deficient HS-5 stroma cells

ABSTRACT: LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effect of LYN kinase on the leukemia supportive phenotype of the bone marrow stromal cell line HS-5, we generated single cell clones of LYN deficient cells. These cells were analyzed in a Multi-Omic approach, comprising four "Omic" layers [microarray-based transcriptome, label-free quantitative proteome and secretome, and SILAC-labelled phosphoproteome (phospho-tyrosine (pYome))] and analyzed integratively. Raw data of the single "Omic" layers are deposited in different repositories and linked bel

ORGANISM(S): Homo sapiens (human)

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PROVIDER: S-BSST703 | biostudies-other |

REPOSITORIES: biostudies-other