Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms

ABSTRACT: Background COVID-19 has caused millions of deaths globally, yet the cellular mechanisms underlying the various effects of the disease remain poorly understood. Recently, a new analytical platform for comprehensive analysis of plasma protein profiles using proximity extension assays combined with next generation sequencing has been developed which allows for multiple proteins to be analyzed simultaneously without sacrifice on accuracy or sensitivity. Methods We analyzed the plasma protein profiles of COVID-19 patients (n = 50) with mild and moderate symptoms by comparing the protein levels in newly diagnosed patients with the protein levels in the same individuals after 14 days. Findings The study has identified more than 200 proteins that are significantly elevated during infection and m

ORGANISM(S): Homo sapiens (human)

SUBMITTER: Wen Zhong 

PROVIDER: S-BSST719 | biostudies-other |

REPOSITORIES: biostudies-other