Identification of Novel Early Pancreatic Cancer Biomarkers KIF5B and SFRP2 From “First contact” interactions in the Tumor Microenvironment

ABSTRACT: Abstract: Background: Pancreatic cancer is one of the most difficult cancers to detect early and most patients die from complications arising due to distant organ metastases. The lack of bona fide early biomarkers is one of the primary reasons for the late diagnosis of this cancer. It is a multifactorial disease and warrants a novel approach to identify novel early biomarkers. Methods: In order to characterize the proteome, Extracellular vesicles (EVs) isolated from different in vitro conditions mimicking interactions between pancreatic cancer epithelial and stromal cells were analyzed by high throughput mass spectrometry. Biological activity of the secreted EVome was analyzed by investigating changes in distant organ metastases and early changes in the microbiome. Candidate biomarkers (

ORGANISM(S): Homo sapiens (human) Mus musculus (mouse)

SUBMITTER:  

PROVIDER: S-BSST794 | biostudies-other |

REPOSITORIES: biostudies-other