A cross-sectional study on fetuin-A gene polymorphism and linkage disequilibrium in patients with urinary calcium oxalate stones

ABSTRACT: Background: Fetuin-A is a plasma glycoprotein, a strong inhibitor of concretion, the polymorphism of which is least explored in kidney stone disease. The study needs to assess the pattern of fetuin-A gene polymorphisms and their linkage disequilibrium(LD) in subjects with and without urinary oxalate stones. Methods: 100 participants were recruited for the study, out of which 50 were cases and 50 were controls. Single nucleotide polymorphisms (SNPs) of fetuin-A c.742C>T and c.766C>G gene were performed with polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). LD between the SNPs was carried out using the SHEsisplus and SNPstat online. Results: Genotypic distribution of fetuin-A c.742C>T and fetuin-A c.766C>G wild and mutant alleles frequencies were statistically in

ORGANISM(S): Homo sapiens (human)

SUBMITTER:  

PROVIDER: S-BSST855 | biostudies-other |

SECONDARY ACCESSION(S): S-EPMC6266652

REPOSITORIES: biostudies-other