Project description:The purpose of this study is to determine if there is an association between hepatitis C infection and kidney cancer. All patients who are diagnosed with kidney cancer and who will either have a biopsy or surgery will be offered to be tested for hepatitis C. The control group will be colon cancer patients. Both groups would be of recent diagnosis (6 months).

| 2110600 | ecrin-mdr-crc

Molecular characterization of a renal cell carcinoma PDX cohort

Project description:Patient-derived xenograft (PDX) models represent an essential tool for the preclinical evaluation of novel targeted therapies and their combinations. In this project, we molecularly characterized a comprehensive panel of RCC PDX models with well conserved molecular and pathological features over multiple passages. PDX samples were subjected to next generation sequencing (NGS). Characterization of cancer-relevant features including driver mutations or cellular processes was performed using mutational and gene expression data in order to identify potential biomarker or treatment targets in RCC. In summary, we reported a newly established and molecularly characterized panel of RCC PDX models with high relevance for translational preclinical research.

| EGAS00001006249 | EGA

Renal papillary cell carcinoma

Project description:Renal papillary cell carcinoma

| PRJNA749556 | ENA

Renal Cell Carcinoma

Project description:Renal cell carcinoma comprises several histological types with different clinical behavior. Accurate pathological characterization is important in the clinical management of these tumors. We describe gene expression profiles in 41 renal tumors determined by using DNA microarrays containing 22,648 unique cDNAs representing 17,083 different UniGene Clusters, including 7230 characterized human genes. Differences in the patterns of gene expression among the different tumor types were readily apparent; hierarchical cluster analysis of the tumor samples segregated histologically distinct tumor types solely based on their gene expression patterns. Conventional renal cell carcinomas with clear cells showed a highly distinctive pattern of gene expression. Papillary carcinomas formed a tightly clustered group, as did tumors arising from the distal nephron and the normal kidney samples. Surprisingly, conventional renal cell carcinomas with granular cytoplasm were heterogeneous, and did not resemble any of the conventional carcinomas with clear cytoplasm in their pattern of gene expression. Characterization of renal cell carcinomas based on gene expression patterns provides a revised classification of these tumors and has the potential to supply significant biological and clinical insights. A disease state experiment design type is where the state of some disease such as infection, pathology, syndrome, etc is studied. Computed

2006-01-31 | E-GEOD-4125 | biostudies-arrayexpress

renal cell carcinoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-06-19 | E-GEOD-66885 | biostudies-arrayexpress