Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

[CMP] [cell line] [SIDM01588] Endometrial Adenocarcinoma

ABSTRACT:

SUBMITTER:

PROVIDER: S-CMO1936 | biostudies-other |

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

A transgenic insect cell line engineered to produce CMP-sialic acid and sialylated glycoproteins.

Project description: Not available

| S-EPMC3612900 | biostudies-literature

Prolidase-proline oxidase axis is engaged in apoptosis induction by birch buds flavonol santin in endometrial adenocarcinoma cell line.

Project description: Not available

| S-EPMC10512030 | biostudies-literature

Expression data from endometrial adenocarcinoma cell line ISK with and without EZH2 knockdown

Project description:The findings indicate that EZH2 may act as a important therapeutic target for treatment of EAC. Furherly, EZH2 knockdown couldinduce G2/M phase arrest and resulted in cell proliferation inhibition. To further investigate how EZH2 overexpression impacted cell proliferation of EAC, Microarray gene expression profiling was performed on ISK cell line with or without EZH2 knockdown.

2020-11-22 | GSE139246 | GEO

Establishment and characterization of VOA1066 cells: An undifferentiated endometrial carcinoma cell line.

Project description: Not available

| S-EPMC7556492 | biostudies-literature

Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line.

Project description: Not available

| S-EPMC6391799 | biostudies-literature

The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol.

Project description:We have determined the gene expression profile induced by 17 alpha-ethynyl estradiol (EE) in Ishikawa cells, a human uterine-derived estrogen-sensitive cell line, at various doses (1 pM, 100 pM, 10 nM, and 1 microM) and time points (8, 24, and 48 h). The transcript profiles were compared between treatment groups and controls (vehicle-treated) using high-density oligonucleotide arrays to determine the expression level of approximately 38,500 human genes. By trend analysis, we determined that the expression of 2560 genes was modified by exposure to EE in a dose- and time-dependent manner (p </= 0.0001). The annotation available for the genes affected indicates that EE exposure results in changes in multiple molecular pathways affecting various biological processes, particularly associated with development, morphogenesis, organogenesis, cell proliferation, cell organization, and biogenesis. All of these processes are also affected by estrogen exposure in the uterus of the rat. Comparison of the response to EE in both the rat uterus and the Ishikawa cells showed that 71 genes are regulated in a similar manner in vivo as well as in vitro. Further, some of the genes that show a robust response to estrogen exposure in Ishikawa cells are well known to be estrogen responsive, in various in vivo studies, such as PGR, MMP7, IGFBP3, IGFBP5, SOX4, MYC, EGR1, FOS, CKB, and CCND2, among others. These results indicate that transcript profiling can serve as a viable tool to select reliable in vitro systems to evaluate potential estrogenic activities of target chemicals and to identify genes that are relevant for the estrogen response.

2009-06-24 | GSE11869 | GEO