Project description:Transcriptional profiles of two PDAC cell lines (CF_PAC1 and PANC1) are highly divergent. Knocking down IGF2BP3 resulted in significant transcriptional divergence at 24H, 48H and 72H compared to control, most strikingly in the PANC1 cell line. The dominant affect of knockdown was widespread reduction in expression levels of genes functionally enriched for Proliferation, TNFA signalling and Apoptosis. This highlights IGF2BP3 in these cell lines to be acting as a positve regulator of gene programs broadly associated with progression through the cell cycle and identifies many candidate IGF2BP3-linked genes. A high confidence, consistent motif of genes identified as IGF2BP3-regulated in both cell lines included the genes SLC22A18, GET3 and CCNG1.

2026-05-31 | GSE248031 | GEO

Pancreatic cancer organoid

Project description:Organoids from KPC pancreatic tumor tissue was treated with growth medium or conditional medium of mast cells treated with WT or BAG6 KO EVS of Pan02.

2024-12-31 | E-MTAB-13570 | biostudies-arrayexpress

Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma.

Project description: Not available

| S-EPMC7766822 | biostudies-literature