Project description:Burkitt lymphoma (BL) is a highly aggressive B cell non-Hodgkin lymphoma (B-NHL), which originates from germinal center (GC) B cells and harbors translocations deregulating the MYC oncogene. A comparative analysis of microRNAs (miRNAs) expressed in normal and malignant GC B cells identified miR-28 as significantly down-regulated in BL, as well as in other GC-derived B-NHL. We show that re-expression of miR-28 impairs cell growth and clonogenic properties of BL cells by modulating several targets including MAD2L1, a component of the spindle checkpoint whose down-regulation is essential in mediating miR-28-induced growth-arrest, and BAG1, an activator of the ERK pathway.

2014-06-01 | GSE56268 | GEO

B-cell activating factor (BAFF) stimulation of Burkitt Lymphoma cell line

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-05-23 | GSE100112 | GEO

Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma.

Project description: Not available

| S-EPMC6717587 | biostudies-literature

Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression.

Project description: Not available

| S-EPMC1614712 | biostudies-literature

Chimeric antigen receptor T cells for mature B-cell lymphoma and Burkitt lymphoma.

Project description: Not available