Project description:Cholangiocyte organoids provide a powerful tool for characterizing bile duct epithelium and expanding cholangiocytes for tissue engineering purposes. However, this involves invasively obtained tissue-biopsies via surgery which is not preferential and limits the patient-specific capacities of these cultures. To overcome this, organoid culture were initiated from minimal invasive bile-samples obtained during routine clinical procedures. Characterization revealed that these bile-cholangiocyte organoids originate from the extrahepatic bile duct and are capable to repopulate human extrahepatic bile duct scaffolds. With this, bile duct tissue engineering as well as personalized disease modelling is in sight.

2020-11-19 | GSE156519 | GEO

Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.

Project description: Not available

| S-EPMC4054607 | biostudies-literature

Development and validation of a prognostic nomogram for extrahepatic bile duct adenocarcinoma.

Project description: Not available

| S-EPMC9668252 | biostudies-literature

Positive autoregulation of Sox17 is necessary for gallbladder and extrahepatic bile duct formation.

Project description: Not available

| S-EPMC11829758 | biostudies-literature

Hedgehog Signaling Modulates Interleukin-33-Dependent Extrahepatic Bile Duct Cell Proliferation in Mice.

Project description: Not available