Kidney Models - A success Story

ABSTRACT: Two renal cell-lines (human and rat) were assayed for gene changes resulting from carcinogen exposure in order to develop models for detecting carcinogens. The novel RPTEC/TERT1 cell was found to maintain excellent characteristics of the proximal tubule including transport capabilities and maintenance of a primary cilium. It also showed normal chromosomes and nuclear stability. It was therefore chosen as the human renal cell model. The NRK-52E cell line was chosen as the rat model in order to incorporate interspecies comparison and in vitro - in vivo comparison.

SUBMITTER:  

PROVIDER: S-DIXA-003 | biostudies-other |

REPOSITORIES: biostudies-other