Interferon-related transcriptional program is induced by chronic hepatitis E infection in kidney-transplant recipients

ABSTRACT: Background: Hepatitis E Virus (HEV) is a new causative agent of chronic hepatitis in solid organ transplant recipients in Europe. Factors associated with the occurrence and persistence of chronic HEV infection remain largely unknown but chronic evolution seems to be the consequence of host’s immunological factors rather than of viral factors. Method: In a prospective case-control study, we have determined in whole blood of chronically HEV-infected kidney-transplant recipients the host response using microarray technology. Results: Chronically HEV-infected kidney-transplant recipients exhibited a specific transcriptional program, in which interferon effectors were prominent. The intensity of expression of each signature’s gene was significantly lower in patients who were subsequently cleare

ORGANISM(S): Homo sapiens

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PROVIDER: S-DIXA-D-1122 | biostudies-other |

REPOSITORIES: biostudies-other