Aberrant DNA methylation at genes associated with a stem cell-like phenotype in cholangiocarcinoma tumors

ABSTRACT: Genetic abnormalities of cholangiocarcinoma (CCA) have been widely studied; however, epigenomic changes related to cholangiocarcinogenesis have been less well characterized. We have profiled the DNA methylomes of 28 primary CCA and six matched adjacent normal tissues using Infinium’s HumanMethylation27 BeadChips with the aim of identifying gene sets aberrantly epigenetically regulated in CCA. Using a linear model for microarray data we identified 1610 differentially methylated autosomal CpG sites with 809 CpG sites (representing 603 genes) being hypermethylated and 801 CpG sites (representing 712 genes) being hypomethylated in CCA versus adjacent normal (false discovery rate ≤ 0.05). Gene Ontology and Gene Set Enrichment analyses identified gene sets significantly associated with hypermeth

ORGANISM(S): Homo sapiens

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PROVIDER: S-DIXA-D-1131 | biostudies-other |

REPOSITORIES: biostudies-other