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Transcription profiling of 57 hepato cellular carcinoma tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools

ABSTRACT: A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). 65 samples on Affymetrix HG-U133A GeneChips arrays (57 tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools). Identification of six subgroups of Hepatocellular carcinoma (HCC) closely associated with clinical and genetic annotations (esp. risk factors and genetic alterations). Identification of a 16-gene diagnostic predictor of class membership, as well as a 5-gene signature predicting patient prognosis irrespective of HCC sub-group and which outperforms common clinical prognostic markers. Validation of both gene signatures in an independent set of 63 HCC.

ORGANISM(S): Homo sapiens

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PROVIDER: S-DIXA-D-1188 | biostudies-other |

REPOSITORIES: biostudies-other

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