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RNA-seq of human melanoma samples

ABSTRACT: In this study, mutations present in a series of human melanomas (stage IV disease) will be determined, using autologous blood cells to obtain a reference genome. From each of the samples that are analyzed, tumour-infiltrating T lymphocytes have also been isolated. This offers a unique opportunity to determine which (fraction of) mutations in human cancer leads to epitopes that are recognized by T cells. The resulting information is likely to be of value to understand how T cell activating drugs exert their action.

ORGANISM(S): Homo sapiens

SUBMITTER: The Wellcome Trust Sanger Institute 

PROVIDER: S-ECPF-ERAD-61 | biostudies-other |

REPOSITORIES: biostudies-other

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