Transcription profiling of human NSCLC cell lines treated with Trichostatin A and vorinostat to test Anti-tumor Activity of Histone Deacetylase Inhibitors

ABSTRACT: In order to ascertain the potential for histone deacetylase (HDAC) inhibitor-based treatment in non-small cell lung cancer (NSCLC), we analyzed the anti-tumour effects of Trichostatin A (TSA) and suberoylanilide hydroxamic acid (vorinostat) in a panel of 16 NSCLC cell lines via MTT assay. TSA and vorinostat both displayed strong anti-tumor activities in a proportion of NSCLC cell lines, and suggesting the need for the use of predictive markers to select patients receiving this treatment. There was a strong correlation between the responsiveness to TSA and vorinostat (P < 0.0001). To identify a molecular model of sensitivity to HDAC inhibitor treatment in NSCLC, we conducted a gene expression profiling study using cDNA arrays on the same set of cell lines and related the cytotoxic activit

ORGANISM(S): Homo sapiens

SUBMITTER: Gemma Akihiko 

PROVIDER: S-ECPF-GEOD-10089 | biostudies-other |

REPOSITORIES: biostudies-other