Transcription profiling of human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism reveals a novel lung cancer gene signature mediates metastatic bone colonization by a dual mechanism

ABSTRACT: Bone is a frequent target of lung cancer metastasis, which is associated with significant morbidity and a dismal prognosis. To identify and functionally characterize genes involved in the mechanisms of osseous metastasis we developed a murine lung cancer model. Comparative transcriptomic analysis identified genes encoding signaling molecules (such as TCF4 and PRKD3), and cell anchorage related proteins (MCAM, and SUSD5), some of which were basally modulated by TGFbeta in tumor cells and in conditions mimicking tumor-stroma interactions. Triple gene combinations induced not only high osteoclastogenic activity but also a marked enhancement of global metalloproteolytic activities in vitro. These effects were strongly associated with robust bone colonization in vivo, whereas this gene subset w

ORGANISM(S): Homo sapiens

SUBMITTER: Rivas Javier De Las 

PROVIDER: S-ECPF-GEOD-10096 | biostudies-other |

REPOSITORIES: biostudies-other