Transcription profiling of human non-small cell lung cancer adenocarcinoma and squamous cell carcinoma subtypes

ABSTRACT: Non-small cell lung cancer (NSCLC) can be classified into the major subtypes adenocarcinoma (AC) and squamous cell carcinoma (SCC) subtypes. Although explicit molecular, histological and clinical characteristics have been reported for both subtypes, no specific therapy exists so far. However, the characterization of suitable molecular targets holds great promises to develop novel therapies in NSCLC. In the present study, global gene expression profiling of 58 human high grade NSCLC specimens revealed large transcriptomic differences between AC and SCC subtypes: More than 1.700 genes were found to be differentially expressed. Experiment Overall Design: The NSCLC patient collective was composed of the histological subtype adenocarcinoma (n=40) and squamous cell carcinoma (n=18). We subjected

ORGANISM(S): Homo sapiens

SUBMITTER: Kuner Ruprecht 

PROVIDER: S-ECPF-GEOD-10245 | biostudies-other |

REPOSITORIES: biostudies-other